Table 2 The distances (Å) between atoms of residues from opposite sides of the substrate binding cleft indicating the very closed, closed and open states of substrate binding channel
Side 1 | Side 2 | TPP-TLL (PDB id: 4FLF) | TLL (PDB id:4ZGB) | Detergent-treated (PDB id: 1GT6) |
|---|---|---|---|---|
86 ILE CD1 | ILE259 CD2 | 3.99 | 5.48 | 19.35 |
87 GLU CG | LEU255 CD1 | 4.39 | 5.99 | 20.17 |
89TRP CZ3 | VAL203 CG2 | 4.12 | 4.62 | 7.78 |
90ILECD1 | VAL203 CG2 | 4.14 | 4.47 | 18.12 |
93LEUCD2 | PRO207CG | 4.21 | 5.12 | 9.03 |
95 PHE O | TYR213-OH | 3.20 | 3.40 | 2.57 |
95 PHECZ | PRO208 CD | 3.81 | 5.34 | 8.21 |
95 PHECE2 | PHE211CE1 | 4.33 | 5.11 | 6.90 |
95PHE CD2 | PHE211CZ | 3.86 | 4.20 | 6.18 |
95PHE CG | PHE211CG | 4.37 | 4.65 | 6.07 |
95PHE CD2 | PHE211CD2 | 3.67 | 4.43 | 5.32 |
95PHE CD2 | PHE211CD1 | 4.06 | 5.15 | 7.60 |
95PHE CD2 | PHE211CE1 | 4.06 | 4.87 | 7.39 |
95PHE CD2 | PRO208CD | 4.04 | 5.56 | 7.35 |
95PHE CZ | PRO208 CD | 3.81 | 5.34 | 7.45 |
95PHE CD1 | PRO207CG | 3.69 | 3.74 | 5.84 |
95PHE CE2 | PRO208CG | 4.70 | 6.30 | 8.39 |
97 LEUCG | TYR213 CZ | 3.70 | 4.22 | 9.23 |