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Sustainable Chemical Processes

Table 7 PMI, e-factor, and atom economy of the developed process

From: Facile approach for the synthesis of rivaroxaban using alternate synthon: reaction, crystallization and isolation in single pot to achieve desired yield, quality and crystal form

Process

Theoretical PMI

Actual PMI

Aqueous PMI

Solvent PMI

e-factor

Atom economy

Megafine process

4.13

7.40

2.04

76.6

85.13

37.97

U.S. Pat. 7,576,111

2.24

28.14

25.0

415.3

455.95

44.91

  1. By-products and impurities formed during the deprotection of phthalimide group in 8 to form 9 by LC–MS in reaction mass as well as in the isolated solid of compound 9.
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