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Table 6 Trend data of residual solvent, HPLC purity and yield of three pilot batches

From: Facile approach for the synthesis of rivaroxaban using alternate synthon: reaction, crystallization and isolation in single pot to achieve desired yield, quality and crystal form

Sr. no.

Solvent content by GC-HS in ppm

HPLC purity (%)

Yield (%)

DMSO

Acetonitrile

Methanol

1

9

11

14

15

1

1,068

238

352

99.81

0.01

ND

0.02

ND

85.2

2

991

226

368

99.81

0.01

ND

0.03

ND

85.3

3

969

241

407

99.83

0.01

ND

0.02

ND

85.9

  1. ND not detected.