Facile approach for the synthesis of rivaroxaban using alternate synthon: reaction, crystallization and isolation in single pot to achieve desired yield, quality and crystal form

Sustainable Chemical Processes

Table 5 HPLC trend data, yield, and acetonitrile content by GC in 1

Expt. no.	DMSO (Vol^a)	ACN (Vol^a)	MeOH (Vol^a)	Yield (%)	Content by HPLC (%)					ACN content by GC (ppm)
Expt. no.	DMSO (Vol^a)	ACN (Vol^a)	MeOH (Vol^a)	Yield (%)	1	14	15	NP	11	ACN content by GC (ppm)
1	5	10	–	69.1	99.85	0.06	0.03	0.02	ND	1,980
2	3	8	–	75	99.86	0.07	0.02	0.02	ND	753
3	4	10	–	71	99.51	ND	0.14	ND	ND	NA
4	4	6	4	71	99.51	0.15	0.03	ND	ND	580
5	4	4	6	75.0	99.56	0.06	ND	ND	ND	256
6	4	6	4	75.1	99.72	0.12	ND	0.02	ND	NA
7	4	6	9	80.2	99.68	0.05	ND	0.05	ND	337
8	4	4	6	87	99.79	0.04	0.03	0.03	ND	424
9	4	4	4	–	99.55	0.06	ND	0.01	ND	371
10	4	2	6	–	99.68	0.05	0.04	ND	ND	283
11	6	2	6	86.4	99.81	0.04	ND	0.04	ND	110
12	6	2	6	84.2	99.84	0.03	0.02	ND	ND	135