Sustainable Chemical Processes

Table 3 Results obtained from different routes (A, B and C) for synthesis of 1

From: Facile approach for the synthesis of rivaroxaban using alternate synthon: reaction, crystallization and isolation in single pot to achieve desired yield, quality and crystal form

Route	Compd. 9 (g)	Substrate (mol. eq.)	Solvents	Time (h)	Temp (°C)	HPLC purity (%)		Yield (%)
Route	Compd. 9 (g)	Substrate (mol. eq.)	Solvents	Time (h)	Temp (°C)	Reaction mass	Isolated solid	Yield (%)
A	10.0	11 (1.05)	DMSO	1.0	40	78.0	99.85	86.0
B	10.0	12 (1.20)	ACN	5.0	80	60.8	91.0	34.5
C	10.0	13 (1.50)	ACN	23.0	75	NA	67.17	NI

NA not analyzed, NI not isolated.

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