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Table 2 Yield and quality data of amine compound 9 from scale-up batches

From: Facile approach for the synthesis of rivaroxaban using alternate synthon: reaction, crystallization and isolation in single pot to achieve desired yield, quality and crystal form

No.

Comp 8 (kg)

MeNH2 sol. (L)

MeOH (L)

Temp (°C)

Yield (%)

Quality details by HPLC (%)

9

8

7

6

5

16

1

2.88

2.93

28.8

60–65

87.5

99.76

ND

0.04

ND

ND

ND

2

2.87

2.92

28.7

60–65

86.0

99.80

ND

0.02

ND

ND

ND

3

2.90

2.95

29.0

60–65

85.0

99.86

0.01

0.02

ND

ND

ND

  1. ND not detected.