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Table 4 Synthesis of various 5-acrylate-2ʹ-deoxuridine analogues 7, 41-49

From: Heck and Sonogashira couplings in aqueous media – application to unprotected nucleosides and nucleotides

Entry

Acrylate

Product

Yield (%)

1

32

90

2

33

90

3

4

45

4

34

45

5

35

45

6

36

40

7

37

45

8

38

35

9

39

60

10

40

51