Sustainable Chemical Processes

Table 10 Synthesis of 5-alkynyl nucleoside analogues 94-103

From: Heck and Sonogashira couplings in aqueous media – application to unprotected nucleosides and nucleotides


Entry	R ¹	R ²	R ³	Starting material	R ⁴	Product	Yield (%)
1	NH₂	H	H	60		94	88
2	NH₂	H	H	60		95	89
3	NH₂	H	H	60		96	98
4	NH₂	H	H	60		97	98
5	NH₂	H	OH	92		98	53
6	NH₂	H	OH	92		99	74
7	OH	H	H	93		100	86
8	OH	H	H	93		101	85
9	OH	H	H	93		102	85
10	OH	H	H	93		103	84

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