Skip to main content

Table 10 Synthesis of 5-alkynyl nucleoside analogues 94-103

From: Heck and Sonogashira couplings in aqueous media – application to unprotected nucleosides and nucleotides

Entry R 1 R 2 R 3 Starting material R 4 Product Yield (%)
1 NH2 H H 60 94 88
2 NH2 H H 60 95 89
3 NH2 H H 60 96 98
4 NH2 H H 60 97 98
5 NH2 H OH 92 98 53
6 NH2 H OH 92 99 74
7 OH H H 93 100 86
8 OH H H 93 101 85
9 OH H H 93 102 85
10 OH H H 93 103 84