Sustainable Chemical Processes

Table 1 Synthesis of 5-vinyl nucleoside analogues 7-9

From: Heck and Sonogashira couplings in aqueous media – application to unprotected nucleosides and nucleotides


Entry	Alkene	Ligand	Product	Yield (%) ^a
1	4	None		64
2	4	TPPTS		74
3	5	None		72
4	5	TPPTS		71
5	6	None		82
6	6	TPPTS		81

^aAverage isolated yields of two independent trials.

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