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Table 1 Synthesis of 5-vinyl nucleoside analogues 7-9

From: Heck and Sonogashira couplings in aqueous media – application to unprotected nucleosides and nucleotides

Entry Alkene Ligand Product Yield (%) a
1 4 None 64
2 TPPTS 74
3 5 None 72
4 TPPTS 71
5 6 None 82
6 TPPTS 81
  1. aAverage isolated yields of two independent trials.