Sustainable Chemical Processes

Table 2 Overall yields of LNA monomers for the reported classical chemical and chemo-enzymatic convergent synthesis

From: An astute synthesis of locked nucleic acid monomers

LNA monomer	Overall yield (%) (Scheme 3 )*	Overall yield (%) (Scheme 5 )*
U; 1a	69.6	72.4
T; 1b	51.1	63.9
A; 1c	34.7	54.1
C; 1d	48.6	55.9

*The overall yields have been calculated from dihydroxy compound 10.

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