Table 1 Some interesting examples of organic compounds synthesized in the authors’ laboratory exploiting catalytic promiscuity
From: Enzyme promiscuity: using the dark side of enzyme specificity in white biotechnology
Structure of the compound | Substrate and reaction conditions | Reference |
|---|---|---|
| Substrate: 5-Hydroxy-endo tricyclo [5.2.1.02,6] deca-4,8-dien-3-one and vinyl acetate | [40] |
Biocatalyst: Novozyme 435 | ||
Solvent: Vinyl acetate (substrate) containing 10 % (v/v) pyridine/DMF | ||
| Substrate: p-nitrobenzaldehyde and ethyl acetoacetate | [41] |
Biocatalyst: Lipases from Candida antarctica lipase B, Mucor javanicus, Mucor miehei, Candida rugosa and Novozyme 435 | ||
Solvent: Aqueous organic co-solvent mixtures were used as the solvent | ||
| Substrate: p-nitrobenzaldehyde and acetyl acetone | [42] |
Biocatalyst: Lipases from Candida antarctica lipase B, Mucor javanicus, Mucor miehei, Burkholderia cepacia and Novozyme 435 | ||
Solvent: Aqueous organic co-solvent mixtures | ||
| Substrate: p-nitrobenzaldehyde | [43] |
Biocatalyst: Novozyme 435 | ||
Solvent: Aqueous buffer |
