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Table 1 Some interesting examples of organic compounds synthesized in the authors’ laboratory exploiting catalytic promiscuity

From: Enzyme promiscuity: using the dark side of enzyme specificity in white biotechnology

Structure of the compound Substrate and reaction conditions Reference
Substrate: 5-Hydroxy-endo tricyclo [5.2.1.02,6] deca-4,8-dien-3-one and vinyl acetate [40]
Biocatalyst: Novozyme 435
Solvent: Vinyl acetate (substrate) containing 10 % (v/v) pyridine/DMF
Substrate: p-nitrobenzaldehyde and ethyl acetoacetate [41]
Biocatalyst: Lipases from Candida antarctica lipase B, Mucor javanicus, Mucor miehei, Candida rugosa and Novozyme 435
Solvent: Aqueous organic co-solvent mixtures were used as the solvent
Substrate: p-nitrobenzaldehyde and acetyl acetone [42]
Biocatalyst: Lipases from Candida antarctica lipase B, Mucor javanicus, Mucor miehei, Burkholderia cepacia and Novozyme 435
Solvent: Aqueous organic co-solvent mixtures
Substrate: p-nitrobenzaldehyde [43]
Biocatalyst: Novozyme 435
Solvent: Aqueous buffer