Sustainable Chemical Processes

Table 4 novel analogues of compound 5 (Scheme 2 )

From: Improved one-pot synthesis of N, N-diisopropyl-3-(2-Hydroxy-5-methylphenyl)-3-phenyl propanamide; a key intermediate for the preparation of racemic Tolterodine

Entrty	Coumarin	Amine	Product	Melting range	Yield
5		MIPA^a		136-139°C	98%
5a		MIPA		132-136°C	88%
5b		MIPA		162-166°C	97%
5c		MIPA		125-128°C	90%

^aIsopropylamine.

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