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Table 4 novel analogues of compound 5 (Scheme 2 )

From: Improved one-pot synthesis of N, N-diisopropyl-3-(2-Hydroxy-5-methylphenyl)-3-phenyl propanamide; a key intermediate for the preparation of racemic Tolterodine

Entrty Coumarin Amine Product Melting range Yield
5 MIPAa 136-139°C 98%
5a MIPA 132-136°C 88%
5b MIPA 162-166°C 97%
5c MIPA 125-128°C 90%
  1. aIsopropylamine.