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Table 3 Novel analogues of compound 4

From: Improved one-pot synthesis of N, N-diisopropyl-3-(2-Hydroxy-5-methylphenyl)-3-phenyl propanamide; a key intermediate for the preparation of racemic Tolterodine

Entrty Coumarin Amine Product Melting range Yield
4 DIPA 169- 173°C (literature mp 170-173°C)7 75%
4a DIPA 151-155°C 77%
4b DIPA 168-172°C 73%
4c DIPA 169-173°C 75%