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Table 2 Screening of catalyst for the synthesis of compound 4

From: Improved one-pot synthesis of N, N-diisopropyl-3-(2-Hydroxy-5-methylphenyl)-3-phenyl propanamide; a key intermediate for the preparation of racemic Tolterodine

Entry Coumarin Catalyst Moles Temparature Yield (%)a
1. 2 Acetic acid 1 25-30°C 50
2. 2 Acetic acid 2 25-30°C 55
3. 2 Acetic acid 3 25-30°C 57
4. 2 Acetic acid 4 25-30°C 75
5. 2 Acetic acid 5 25-30°C 75
  1. aisolated yields.