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Table 2 Screening of catalyst for the synthesis of compound 4

From: Improved one-pot synthesis of N, N-diisopropyl-3-(2-Hydroxy-5-methylphenyl)-3-phenyl propanamide; a key intermediate for the preparation of racemic Tolterodine

Entry

Coumarin

Catalyst

Moles

Temparature

Yield (%)a

1.

2

Acetic acid

1

25-30°C

50

2.

2

Acetic acid

2

25-30°C

55

3.

2

Acetic acid

3

25-30°C

57

4.

2

Acetic acid

4

25-30°C

75

5.

2

Acetic acid

5

25-30°C

75

  1. aisolated yields.