Table 1 Comparison of enzymatic and chemical glycosylation in terms of Space-Time Yield and E-factor
From: β-Glycosidases: An alternative enzyme based method for synthesis of alkyl-glycosides
Glycosylation method | Glycosyl donor | Product | Efactor (kg waste per kg product) | Space-time yield (g/l/d) | Reference |
|---|---|---|---|---|---|
Direct glycosylation (by glycosidase) | Glucose | Glcβ-O(CH2)6OH | 0.5 | 5.6 | [48] |
Transglycosylation | Lactose | Galβ-O(CH2)6OH | 3 | 2380 | [49] |
(by β-galactosidase) | |||||
Koenigs-Knorr method | Galactose | Galβ-OPh-2-NO2 | 10 | 26 | [50] |
Direct glycosylation (by glycosidase) | Glucose | Glcβ-OCH(CH3)CHCH2 | 2 | 10 | [51] |
Koenigs-Knorr method | Glucose | Glcβ-OCH(CH3)CHCH2 | 20 | 36 | [52] |